Structural characterization of viral fusion proteins

Structural characterization of viral fusion proteins

Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural ch...

The Structural Characterization of Tumor Fusion Genes and Proteins

Chromosomal translocation, which generates fusion proteins in blood tumor or solid tumor, is considered as one of the major causes leading to cancer. Recent studies suggested that the disordered fragments in a fusion protein might contribute to its carcinogenicity. Here, we investigated the sequence feature near the breakpoints in the fusion partner genes, the structure features of breakpoints ...

Identification of Viral Structural Proteins

Viral Gastroenteritis Unit, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 303331*; Laboratory of Virus Morphology, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing, China2; Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 7703O3; Department of Pediatrics, The Johns Hopkins Hospit...

Identification and characterization of viral structural proteins of infectious salmon anemia virus.

Infectious salmon anemia virus (ISAV) is an unclassified Orthomyxovirus that has been shown to contain a segmented genome with eight single-stranded RNA species coding for 10 viral proteins. Four major structural proteins were characterized in the present study: two glycosylated proteins with estimated molecular masses of 42 and 50 kDa, one 66-kDa phosphoprotein, and one 22-kDa protein. Examina...

Anemia Virus Structural Proteins of Infectious Salmon Identification and Characterization of Viral